Research Scientist & Manager
A neurophysiologist and engineer with broad experience in research and administration.
Oct. 1996-Jan. 2000 DPhil (PhD) Neuroscience, University of Oxford, Diploma 2002
Department of Pharmacology & Medical Research Council
Sept. 1992-May 1996 BSc Chemical Engineering, University of South Florida
Department of Chemical Engineering, GPA: 3.52/4.00
DPhil (PhD) Thesis Title
Differential involvement of glutamate receptors in neuronal responses of the cerebral cortex. http://ora.ox.ac.uk/
Intraoperative neurophysiological monitoring for deep brain stimulation. In vivo electrophysiology encompassing field potential, multichannel and intracellular/juxtacellular recordings. Neuronal labeling with a tracer or viral-mediated protein expression and microiontophoretic application of drugs. In vitro patch clamp, cell culture, immunohistology and multiphoton imaging.
Computer Skills: Fortran, Pascal, C++, DOS, UNIX
Software: ASPEN, TK Solver, Matlab, StatView, Prism, CAD, Adobe Photoshop, Leica Imaging, Spike2, Clampex, Axograph, Igor Pro, PULSE, Offline Sorter, NeuroExplorer, MCS, Guideline 4000 LP+, Distance Expert-Neurophysiology, Guideline 4000 LP+, Microsoft.
• GNC Intensive Course on Intraoperative Neurophysiological Monitoring
• Two-week course at the Neuroscience School of Advanced Studies (Siena, Italy).
• Three-month research collaboration with Dr. György Buzsáki at the Center for Molecular and Behavioral Neuroscience, University of Rutgers, Newark, New Jersey.
• Two-week course at the Marine Biological Laboratory (Plymouth, UK) titled ‘MicroelectrodeTechniques for Cell Physiology.’
• Two-month independent study to determine the diffusion coefficients of control release drugs through supercritical fluid chromatography at the University of South Florida.
PAST AND PRESENT AFFILIATIONS RECOGNITION
Innovative Med Initiative (NEWMEDS) IWT Flander Res Fellow, 2012/13
SFN, Soc Neurosci/FENS, Fed Euro Neurosci Max Planck Fellow, 2006-2009
BNA, British Neurosci Assoc Oriel College Grad Scholar, 1998/99
Omega Chi Epsilon Chem Eng Honor Soc. BNA Travel Bursar, 1998
Tau Beta Pi (TBP), National Eng Honor Soc (Pres) Dale-Rushton Physiol Fund, 1998
AIChE, Am Inst Chem Eng (Sec) TBP Kelly Clarke Scholar, 1996
SHPE, Soc Hispanic Prof Eng (Sec) National Hispanic Scholar, 1993
SWE, Soc Women Eng USF Alum Assoc. Scholar, 1995/96
LANGUAGES MENTORING REVIEWING
English & Spanish (Fluent) SFN Mentor Program EU Expert Evaluator; NPG Review
German & Dutch (Beginner) MPI Minerva-FemmeNet Editorial Board Insight Med Publish
Insight Medical Publishing LLC, Wilmington, DE 2017-current
Editorial Board Member providing judgement on the decision to publish articles in J Biomed Sci.
Greenville Neuromodulation Center/Thiel College/FHC Inc., Greenville, PA 2016-current
Intraoperative Neurophysiologist Consultant and Principal Research Scientist for deep brain stimulation guidance and development. Greenville Neuromodulation Center Thiel College Visiting Scholar.
Expert Evaluator, European Commission Horizon 2020, Brussels, Belgium 2016-current
Evaluate grant proposals for the Horizon 2020 EU Framework Program for Research & Innovation.
Instructor, Dept. of Psychology, Western Washington University, Bellingham, WA 2015
Instructor in the Behavioral Neuroscience BSc Program for PSY 220 and PSY 320 courses covering basic concepts and advanced topics for the biological basis of brain behavior. Teaching modules included Anatomy & Physiology, Neural Circuits & Behavior and Psychiatric Disorders.
Postdoctorate Scientist, Janssen NV, Johnson & Johnson Inc., Beerse, Belgium 2009 – 2013
Set up in vitro and in vivo electrophysiological equipment for brain slice patch clamp, multielectrode array and multiunit recordings. Designed projects that translate from psychiatric phenotypes to therapeutic biomarkers as part of the largest industry-academic consortium, IMI-NEWMEDS. Presented my findings at international conferences and managed graduate students. Prepared proposals for project licences in animal experimentation and engaged as a company representative by providing lab tours to the external scientific community.
Research Fellow, Max Planck Inst. for Med. Res., Heidelberg, Germany 2006 – 2009
Investigated NMDA receptor subtypes in hippocampal spike-time dependent plasticity in vitro. Performed viral injections of reporter proteins in vivo followed by whole-cell patch delivery of Ca2+ fluorophores for combined Two-Photon imaging and electrophysiological recordings in rodent brain slices. Promoted policy to maintain women in science through the Minerva-FemmeNet organization.
Research Project Manager, Holburn Biomedical Corp., Ontario, Canada 2003 – 2005
Managed a lab and set up an in vivo model to study the pervasiveness of colonic ischemia following antagonism of 5-HT3 receptors for irritable bowel syndrome. Developed surgical techniques to record intestinal blood flow and perfusion as well as simultaneous oxygen tension measurements with ultrasound flowmetry, laser Doppler and polarography, respectively. Responsible for acute and chronic studies and wrote FDA-reviewable reports and Standard Operating Procedures accredited by ISO9000.
Research Scientist, Electrosols Ltd./Battelle Memorial Org., Oxford, England 2000 – 2003
Formulated active ingredient suspensions or microemulsions and assessed their delivery by the electrohydrodynamic method to the nasal mucosa, oral mucosa, ocular surface and agricultural areas. Performed structural and rheological analysis of solutions via spectroscopy and laser particle size analyzer. Co-Inventorship Patents: 1) Battelle Memorial Institute (2002) WO02076424A1 2) Electrosols Ltd., Keates R. (2002) WO02092142A2 and 3) WO02092142A3.
Production Engineer Intern, Tampa Electric Co., Florida, USA 1994 – 1994
Assessed the causes of boiler tube and header failures with EPRI’s software. Developed a flowsheet using AutoCAD with a full description of the Integrated Gasification Combined Cycle Process of electric generation. Produced AutoCAD blueprint drawings of two industrial wastewater facilities for the installation of a tertiary stage filter in liason with the vendor and survey technicians.
Thermodynamics Teacher Assistant, University of South Florida, USA 1993 – 1994
Provided weekly help sessions and graded exams for the thermodynamic engineering course.
Berberich* S, Pohle* J, Pollard* M, Köhr G (2017). Interplay between global and pathway-specific synaptic plasticity in CA1 pyramidal cells. Manuscript Submitted.
Pollard M, Bartolomé JM, Conn PJ, Steckler T, Shaban H (2014) Medial prefrontal cortex neuronal circuitry modulation by mGluR5 positive allosteric modulator. J Psychopharmacol 28(10): 935-946.
Pollard M, Shaban H (2013). Multichannel recordings in the medial prefrontal cortex during carbachol and group I metabotropic glutamate receptor activation. Soc Neurosci Abstr 520.02
Pollard M, Varin C, Hrupka B, Pemberton DJ, Steckler T (2012) Synaptic transmission changes in fear memory circuits underlie key features of an animal model of schizophrenia. Behav Brain Res. 227(1): 184-193
Pollard M, De Prins E, Van Craenendonck H, Pemberton, DJ, Shaban H (2012) Group I metabotropic glutamate receptor-mediated long-term depression and Ca2+-permeable AMPA receptors interact following fear memory paradigms. FENS Forum Abstr. 471.31
Pollard M, Shaban H (2011) Acute PCP reduces carbachol evoked increase in spiking rate of amygdala neurons: Implications for psychosis. Soc Neurosci Abstr 163.16
Ahnaou A, Heylen A, Husymans H, Biermans R, Pollard M, Shaban H, Karan E, Drinkenburg WHIM (2010) EEG oscillations: A pragmatic translational measure of efficacy for drugs with antipsychotic and cognitive enhancing potential. IPEG Abstr S1.2
Pollard M, Shaban H (2010) Intrinsic and synaptic functioning of the lateral amygdala following acute and chronic dosing of phencyclidine as a schizophrenic model. Soc Neurosci Abstr 817.6
Pollard M, Köhr G (2008) Role of calcium and NMDA receptors in intrinsic and spike-
timing- dependent plasticity in the CA1 region of the hippocampus. FENS Abstr., vol. 4, 215.24
Pollard M, Köhr G (2008) Intrinsic plasticity at the hippocampal Schaffer collateral to CA1 pyramidal cell synapse. Acta Physiologica Abstr., vol. 192, Suppl. 663, PM04-20
Pollard M, Whiteley J, Hess A, Stead R, Grundy D (2005) 5-HT3 receptor antagonism by alosetron does not affect colonic hemodynamics and ischemia-reperfusion during nitric oxide synthase (nos) blockade-induced hypertension in rats. Dig Dis Week Abstr. W1646
Pollard M, Hess A, Stead RH, Grundy D (2005) Evaluation of colonic vascular reactivity following chronic loperamide and alosetron treatment in rats. Dig Dis Week Abstr. S1882
Ferraguti F, Cobden P, Pollard M, Watanabe M, Somogyi P (2004) Immunolocalization of the metabotropic glutamate receptor 1 (mGluR1) in distant classes of interneurons of the rat hippocampal CA1 area. Hippocampus 14(2): 193-215
Pollard M (2000) Ionotropic glutamate receptor-mediated responses in the rat primary somatosensory cortex evoked by noxious and innocuous cutaneous stimulation in vivo. Exp Brain Res 131: 282-292
Pollard M, Kogo N, Roberts JDB, Ferraguti F, Somogyi P (2000) Cell types expressing somatostatin and/or mGluR1 in the rat hippocampal CA1 area. Soc Neurosci Abstr 26: 427.10
Pollard M, Eaton SA (1998) NMDA receptor-mediated component of nociceptive sensory synaptic responses in rat primary somatosensory neurons. Eur J Neurosci Abstr 10(Suppl. 10): 30.04